Dr Gabriella Lindergard

Research Interest

My current work has involved studying the molecular mechanisms behind the clumping phenomena that can occur between P. falciparum infected erythrocytes and platelets. This platelet mediated clumping has been detected both in parasites obtained from malaria patients and in culture-adapted laboratory strains but the basis of the interaction is poorly understood. I have also been involved in the investigations into finding specific malaria parasite ligands for binding to human brain endothelial cells. The overall aim is to identify targets for interventions to treat or prevent cerebral malaria.

CV

2007 – present

  • Postdoc at the University of Edinburgh

1999 – 2002

  • Postdoc at Cornell University, USA.

1995 – 1999

  • PhD at University of Glasgow

1994 – 1995

  • MSc at Liverpool School of Tropical Medicine

1990 – 1993

  • Registered Nurse

Publications

Arman M, Adams Y, Lindergard G, Rowe JA. 2013.

A method for positive and negative selection of Plasmodium falciparum platelet-mediated clumping parasites and investigation of the role of CD36.
PLoS ONE 8: e55453. doi:10.1371/journal.pone.0055453 PDF

Claessens A, Adams Y, Ghumra A, Lindergard G, Buchan C, Andisi C, Bull PC, Mok S, Gupta AP, Wang CW, Turner L, Arman M, Raza A, Bozdech Z, Rowe JA. 2012.

A subset of Group A-like var genes encode the malaria parasite ligands for binding to human brain endothelial cells.
Proceedings of the National Academy of Sciences U S A 109:E1772-1781. doi: 10.1073/pnas.1120461109 PDF

Ziegel PE, Santucci F, Lindergard G, Nydam DV, Wade SE, Schaaf SL, Chang YE, Mohammed HO. 2007.

Evaluation of polymerase chain reaction diagnosis of Cryptosporidium spp in dairy cattle and wildlife.
Veterinary Therapeutics 8(2):148-59

Zakeri S, Lindergard G, Davies RM, Boudin C, Louis F, Hommel M. 2006.

Identification and typing of Camreoonian isolates of P. malariae using monoclonal antibodies against P.brasilianum.
Acta Tropica Aug;99(1):97-101

Nydam DV, Lindergard G, Wade SE, Mohammed HO. 2005.

Risk of infection with Cryptosporidium parvum and Cryptosporidium hominis in dairy cattle in a New York watershed.
American Journal of Veterinary Research Mar;66(3):413-7

Turner CMR, McLellan S, Lindergard G, Bisoni L, Tait A, MacLeod A. 2004.

Human infectivity trait in Trypanosoma brucei: stability, heritability and relationships to SRA expression.
Parasitology Oct;129(Pt 4):445-54

Lindergard G, Nydam DV, Wade SE, Schaaf SL, Mohammed HO. 2003.

The sensitivity of PCR detection of Cryptosporidium oocysts in fecal samples using two DNA extraction methods.
Molecular Diagnosis 7(3-4): 147-53

Lindergard G, Nydam DV, Wade SE, Schaaf SL, Mohammed HO. 2003.

A novel multiplex polymerase chain reaction approach for detection of four human infective Cryptosporidium isolates: Cryptosporidium parvum, types H and C, Cryptosporidium canis, and Cryptosporidium felis in fecal and soil samples.
Journal of Veterinary Diagnostic Investigation May;15(3):262-7

Kato S, Lindergard G, Mohammed HO. 2003.

Utility of the Cryptosporidium oocyst wall protein (COWP) gene in a nested PCR approach for detection infection in cattle. 
Veterinary Parasitology Feb 13;111(2-3):153-9

Nydam DV, Lindergard G, Guard CL, Schaaf SL, Wade SE, Mohammed HO. 2002.

Serological detection of exposure to Cryptosporidium parvum in cattle by ELISA and its evaluation in relation to coprological tests.
Parasitology Research Sep;88(9):797-803

Rubio JM, Post RJ, van Leeuwen WM, Henry MC, Lindergard G, Hommel M. 2002.

Alternative polymerase chain reaction method to identify Plasmodium species in human blood samples: the semi-nested multiplex malaria PCR (SnM-PCR).
Trans R Soc Trop Med Hyg Apr;96 Suppl 1:S199-204

Tait A, Masiga D, Ouma J, MacLeod A, Sasse J, Melville S, Lindegard G, McIntosh A, Turner M. 2002.

Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits.
Philos Trans R Soc Lond B Biol Sci Jan 29;357(1417):89-99

Lindergard G, Wade SE, Schaaf S, Barwick RS, Mohammed HO. 2001.

Detection of Cryptosporidium oocysts in soil samples by enzyme-linked immunoassay.
Veterinary Parasitology Jan 1;94(3):163-76

Denise H, Matthews K, Lindergard G, Croft S, Barrett MP. 1999.

Trypanosomiasis and leishmaniasis: between the idea and the reality of control.
Parasitology Today Feb;15(2):43-5

Lindergard G, Hope M, MacLeod A, Tait A, Turner CMR. 1998.

Human serum resistance in Trypanosoma brucei.
Trans R Soc Trop Med Hyg 92:475-477