Carolyne Kifude

Research interest

My current work focuses on understanding the molecular mechanisms of rosetting, particularly in field isolates. While a lot of studies on rosetting have focused on laboratory adopted lines, mainly of non-African origin, none has focused on characterizing rosetting in field isolates of African origin. This is crucial bearing in mind that rosetting has consistently been associated with severe malaria in African children. I am interested in understanding whether rosetting variants have any clinical relevance and whether children recovering from different syndromes of severe malaria raise variant specific antibodies against rosetting parasites. I am also interested in looking at association between var gene expression and antibody responses against rosetting variants.



  • PhD student, based at KEMRI-wellcome Trust Kilifi


  • MSc degree in parasite Biochemistry at Kenyatta University, Kenya


  • BSc in Zoology/Chemistry (1st Class Hons) at the Maseno University, Kenya

List of publications

Ghumra A, Semblat J-P, Ataide R, Kifude C, Adams Y, Claessens A, Anong DN, Bull PC, Fennell C, Arman M, Amambua-Ngwa A, Walther M, Conway DJ, Kassambara L, Doumbo O, Raza A, Rowe JA. 2012.

Induction of Strain-Transcending Antibodies Against Group A PfEMP1 Surface Antigens from Virulent Malaria Parasites.
PLoS Pathogens 8: e1002665.doi:10.1371/journal.ppat.1002665 PDF

Waitumbi JN, Anyona SB, Hunja CW, Kifude C, Polhemus ME, Walsh DS, Ockenhouse CF, Gray Heppner Jr. D, Leach A, Lievens M, Ripley Ballou W, Cohen JD, Sutherland CJ. 2009.

Impact of RTS,S/AS02A and RTS,S/AS01B on Multiplicity of Infections and CSP T-cell Epitopes of P. falciparum in Adults Participating in a Malaria Vaccine Clinical Trial.
PLoS ONE Nov 17;4(11):e7849

Martin SK, Rajasekariah GH, Awinda G, Waitumbi J, Kifude C. 2009.

Unified Parasite Lactate Dehydrogenase and Histidine-Rich Protein ELISA for Quantification of Plasmodium falciparum.
American Journal of Tropical Medicine and Hygiene 80(4) pp. 516-522

Kifude C, Rajasekariah HG, Sullivan Jr DJ, Stewart VA, Angov E, Martin SK, Diggs CL, Waitumbi JN. 2008.

Characterization of Enzyme Linked Immunosorbent Assay for Plasmodium falciparum Histidine-Rich Protein 2 in Blood, Plasma and Serum.
Clinical and Vaccine Immunology Jun;15(6):1012-8

Kifude C, Polhemus ME, Heppner Jr DG, Withers MR, Ogutu BR, Waitumbi JN. 2007.

Hb Kenya among Luo adults and young children in Malaria Holoendemic Western Kenya: Screened by High Performance Liquid Chromatography and confirmed by Polymerase Chain Reaction.
Hemoglobin 31 (4): 401–408

Waitumbi JN, Kifude C, Heppner GD, Ogutu BR. 2007.

Hb GPhiladelphia or Hb Stanleyville II: When genotype and phenotype do not agree.
European Journal of Haematology Letter to the Editor. ISSN 0902-4